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Commercial growth and development in Alhambra has sprouted in multiple directions, resulting in the following four distinct business districts:

1. Main Street Business District (Main & First Streets) Comprised of numerous restaurants, retail, service and entertainment venues, as well as the Auto Row.

2. Valley Boulevard Business District (Empire Financial Center) Here one will find numerous Asian retail and service-oriented businesses, especially Asian banks, some of which serve as main U.S. headquarters.
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 3. Fremont Avenue Business District Integral to this district are The Alhambra, an office complex that is home to major businesses and respected colleges & universities. An L.A. Fitness Center; Kohl's Department Store and Shops at the Alhambra are across the street; and the L.A. County Public Works headquarters building is also located nearby.

4. Mission-Palm Business District (The Home Depot facility) Numerous small service firms and manufacturing facilities are located in this area, including the Home Depot.
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